Robinson had two receptions on as many targets for 22 yards and a touchdown in Monday's 48-27 win over Indianapolis.

Robinson finally hit pay dirt with the 49ers after being held out of the end zone in his first 11 appearances with the club he signed with this past offseason. The veteran wideout's usage didn't increase with WR Ricky Pearsall (ankle/knee) sidelined Monday, but he was the beneficiary of one of QB Brock Purdy's five touchdown strikes. Even factoring in the rare score, Robinson simply isn't a big enough part of San Francisco's game plan to warrant fantasy consideration in Week 17.

Bourne had three receptions on five targets for 27 yards in Monday's 48-27 win over the Colts.

Bourne was inserted into the starting lineup in place of injured teammate Ricky Pearsall (ankle/knee) and finished fourth in team targets. The 29-year-old Bourne was unable to recreate the gaudy receiving numbers we saw in Weeks 5 and 6 when he was asked to start in place of injured starters then. If Pearsall remains sidelined against the Bears and TE George Kittle (ankle) is also unable to go, then that scenario could produce enough meat on the bone for Bourne to eat in Week 17.

Jennings corralled five of six targets for 71 yards and a touchdown in Monday's 48-27 win over the Colts.

Jennings' short touchdown grab on the 49ers' first possession of the second half extended the wideout's scoring streak four games. The 27-year-old has shown a strong nose for the end zone in the second half of the season as well, scoring seven of his career-best eight touchdowns in 2025 over his last seven starts. Jennings was already being asked to play a larger role on offense with WR Ricky Pearsall (ankle/knee) back on the sidelines, and that role could expand further if TE George Kittle (ankle) is forced to miss time after going down in Monday's win. Things are lining up for Jennings to close out the fantasy campaign with a bang, starting with Sunday's home tilt against the Bears.

Warren brought in three of nine targets for 30 yards in the Colts' 48-27 loss to the 49ers on Monday night.

Warren tied Josh Downs for the team lead in targets, but he wasn't anywhere near as productive as his teammate. The rookie tight end has now been at 45 receiving yards or fewer in five straight games, a far cry from the 61.7 receiving yards he averaged over his first 10 career contests. Warren has seen 15 targets over his first two games with Philip Rivers, however, affording him upside despite recent struggles in a Week 17 home matchup versus the Jaguars.

McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis.

McCaffrey and the Colts' Jonathan Taylor headlined a matchup featuring two of the league's top running backs on Monday Night Football. CMC got the better of Taylor (16-46-1) despite facing the stiffer of the two defenses, doubling the latter's yards from scrimmage and scoring output in a winning effort. McCaffrey pushed his rushing total over the 1,000-yard mark for the season while sitting 151 yards shy of doing the same as a receiver with two games left in the regular season. With the 49ers having a potential path to the No. 1 seed in the NFC, fantasy managers can expect the team to lean heavily on McCaffrey against the Bears in Week 17, especially if star TE George Kittle (ankle) is unable to suit up.

Downs brought in five of nine targets for 65 yards in the Colts' 48-27 loss to the 49ers on Monday night. He also rushed once for three yards.

Downs led the Colts in receptions and tied Tyler Warren for the team lead in targets, once again displaying some solid chemistry with Philip Rivers after catching the latter's first touchdown pass since the 2020 season in Week 15. Downs has drawn a total of 14 targets over his first two games working with the veteran signal-caller, and he's likely to be busy again in a Week 17 home matchup against the Jaguars on Sunday.

Pittman brought in four of five targets for 32 yards in the Colts' 48-27 loss to the 49ers on Monday night.

Pittman tied with Alec Pierce for second in receptions on the night for the Colts, but he continued an extended stretch of middling production. Pittman has now recorded Monday's yardage tally or fewer in five of his last six contests, a stretch where he's played with three different quarterbacks. Pittman's quest to snap out of his funk gets another tough challenge in Week 17, as the Jaguars drop in on the Colts on Sunday.

Pierce brought in all four targets for 86 yards and two touchdowns in the Colts' 48-27 loss to the 49ers on Monday night.

Pierce led the Colts in receiving yards and hauled in impressive 20- and 16-yard touchdown passes in the first half from Philip Rivers. The fourth-year pro doubled his number of scoring grabs on the season with Monday's tally, and he's exceeded 75 receiving yards in five of the last seven games. Pierce is just 129 yards away from his first career 1,000-yard season, a figure he'll look to continue approximating in a Week 17 home matchup against the Jaguars.

San Francisco coach Kyle Shanahan said after Monday's 48-27 win against the Colts that it's too early to know the severity of Kittle's ankle injury, Nick Wagoner of ESPN.com reports.

Kittle missed all of the fourth quarter and some of the third due to the ankle issue, and the outcome of the contest wasn't certain until late, so it appears there's at least some chance the star tight end will miss next Sunday's game against Chicago. With that said, further evaluation is needed to determine how serious of an issue Kittle is dealing with, and he will likely do everything he can to play next week given that there is a lot at stake for San Francisco against the Bears. Despite his early exit Monday, Kittle did plenty for fantasy managers who started him, amassing 115 yards and a touchdown on seven catches. Jake Tonges was effective as the 49ers' pass-catching tight end following Kittle's departure and would be a viable fantasy asset in Week 17 if Kittle is forced to sit out.

Rivers completed 23 of 35 passes for 277 yards with two touchdowns and one interception in the Colts' 48-27 loss to the 49ers on Monday night. He also committed a fumble recovered by Indianapolis.

An extra week of practice following a five-year layoff did wonders for Rivers, who looked appreciably sharper most of the night as compared to his season debut against the Seahawks in Week 15. Rivers led a crisp nine-play, 72-yard drive to open the game that he capped off with a 20-yard touchdown pass to Alec Pierce, and he followed it up with another 16-yard scoring strike to the fleet-footed receiver in the second quarter. Rivers' momentum slowed in the second half, however, although he did lead a 12-play, 65- yard march that culminated with a Jonathan Taylor one-yard touchdown run early in the fourth quarter. The veteran signal-caller ultimately sealed the Colts' loss via a pick-six at the 49ers' 26-yard line with 3:26 remaining, but Rivers displayed impressive command of the offense while connecting with eight different targets overall. Indianapolis' quest for a wild-card berth gets another tough obstacle in Week 17, however, as the division-leading Jaguars pay a visit on Sunday afternoon.