Indianapolis Colts head coach Shane Steichen said that quarterback Anthony Richardson (oblique) would practice on Wednesday. Richardson injured his oblique in the Week 4 win over the Pittsburgh Steelers but then was inactive for last week's loss to the division-rival Jacksonville Jaguars. However, the 22-year-old second-year signal-caller was limited all of last week in practice, so if he takes a step forward this week, he'll have a legitimate chance to return to action in Week 6 versus the division-rival Tennessee Titans. Steichen said earlier this week that Richardson will reclaim his gig as the team's starting QB once he gets past his oblique injury, sending veteran Joe Flacco back to the bench. If Richardson gets more done in practice this week and returns on Sunday against the Titans, he'll be on the QB1/2 borderline for fantasy managers after a rough start in 2024.

Indianapolis Colts head coach Shane Steichen said running back Jonathan Taylor (ankle) will not practice on Wednesday after he missed the Week 5 loss to the division-rival Jacksonville Jaguars with a minor high-ankle sprain. Although Taylor's ankle sprain isn't considered too serious, he's no lock to play in Week 6 against the division-rival Tennessee Titans this Sunday, and a DNP to begin the week isn't a great sign. If the 25-year-old doesn't make much progress in practice this week and is unable to play this weekend, Trey Sermon will once again serve as Indy's lead back, with Tyler Goodson backing him up. In the loss to Jacksonville on Sunday, Sermon played 59% of the offensive snaps and had 10 carries for 38 yards and his second touchdown of the year, adding six catches on six targets for an additional 25 yards. At worst, Sermon will be a plug-and-play RB3/flex option again for fantasy managers if Taylor misses another game.

Houston Texans wide receiver Nico Collins (hamstring) is being placed on the Injured Reserve list on Wednesday, meaning he will have to miss at least the next four games. The star wideout suffered a hamstring injury after catching a 67-yard touchdown pass in the Week 5 win over the Buffalo Bills. Collins was No. 2 in total PPR fantasy points heading into Week 5, so this is obviously a crushing blow for his fantasy managers. He will be ineligible to return until Week 10 against the Detroit Lions. With Collins sidelined, Stefon Diggs could be a top-five fantasy wideout during his absence, and Tank Dell, who has struggled so far, will likely have a WR2/WR3 outlook in most matchups. Deep-league fantasy managers might want to kick tires on veteran Robert Woods, but youngsters Xavier Hutchinson and John Metchie III could become fantasy factors. Tight end Dalton Schultz could also benefit in this situation.

Las Vegas Raiders wide receiver Davante Adams (hamstring) is unlikely to play against the Pittsburgh Steelers, according to ESPN's Jeremy Fowler. The hamstring issue may be more of an excuse at this point to keep Adams off the field while the Raiders search for a trade partner. A report earlier this week stated that Adams is nearing full health. The Jets, Saints, and Steelers seem to be the teams pursuing Adams the hardest. However, the Saints just lost Derek Carr (oblique) for a few weeks. The Jets fired their head coach. Other teams don't seem as eager to match the Raiders' asking price. This will be the third straight game Adams has missed. He likely won't see the field again until he's on a different roster.

Detroit Lions running back Jahmyr Gibbs has failed to catch a pass in the last two games (although he did get 20 yards and a receiving touchdown on a lateral in Week 3). It's the first time in his young career that he's failed to log a reception in back-to-back games. Thankfully for fantasy football, he's averaging 13.5 carries and 71 rushing yards per game and has failed to score a touchdown just once. The Dallas Cowboys have allowed 17 receptions to running backs this season, the fifth-lowest mark in the league. However, the 222 yards they've given up to the position is the sixth-most. Even if Gibbs can't break off a long reception, the Cowboys' defense is banged up and has been susceptible against the run. Gibbs and his counterpart David Montgomery should be viewed as top-12 running backs this week.

Detroit Lions running back David Montgomery looks to continue his scoring ways against the Dallas Cowboys defense in Week 6. The veteran runner has scored a touchdown in all four of Detroit's games this season, despite splitting duties with Jahmyr Gibbs. He's averaging 15.75 carries per game. The Cowboys have allowed the seventh-most fantasy points to running backs and surrendered six touchdowns on the ground through five games. The defensive front-seven is banged up and the Lions' elite offensive line should have little issue opening holes for Monty and Gibbs. Both backs are ranked as RB1s this week in what should be a high-scoring affair in Texas.

Free-agent wide receiver Dante Pettis visited the Dallas Cowboys on Tuesday with the hopes of landing a new contract. Former Jet Denzel Mims also tried out for Dallas. The Cowboys are looking to bolster their wide receiver depth with Brandin Cooks (knee) on Injured Reserve and set to miss at least three more games. Pettis spent training camp with the Chicago Bears this summer but failed to make the final roster. He last appeared in a regular season game in 2022, catching 19 passes for 245 yards with the Bears. Even if Dallas signs one of these receivers, they won't be on the fantasy football radar in any format.

Las Vegas Raiders wide receiver Davante Adams has been the hottest name in the trade market over the last week or two. The veteran wideout has been sidelined since Week 3 due to a hamstring injury, but it doesn't appear to be serious. That being said, Adams figures to be dealt relatively soon. The New York Jets and New Orleans Saints were the favorites to land the superstar wideout. However, those trade talks may have slowed down, according to Adam Schefter. The Jets have fired head coach Robert Saleh and their season is headed in the wrong direction quickly. While the Saints just lost quarterback Derek Carr (oblique) for likely multiple weeks, which could put their season in jeopardy. Both the Jets and Saints aren't likely to give up assets to acquire Adams if they aren't going to be competitive this season. The assumption is both teams probably still have interest, but it sounds like trade discussions have slowed down a bit.

Seattle Seahawks tight end Pharaoh Brown (groin) returned to practice as a full participant during Tuesday's session. The 30-year-old was a limited participant during Monday's walkthrough, but appears to be feeling better now. That is good news for Brown as the Seahawks head into a Thursday night matchup against the San Francisco 49ers. Brown has been quiet this season and had only one reception for seven yards last week. He figures to serve as depth with Noah Fant being the primary tight end and AJ Barner has started getting involved as well. Brown can be left on the waiver wire ahead of this Week 6 matchup.

The Denver Broncos have signed wide receiver A.T. Perry to their practice squad on Tuesday. The 24-year-old was recently released by the New Orleans Saints after spending his rookie campaign with them in 2023. The former sixth-round continued to be a healthy scratch on gameday, so the team eventually decided to move on. Perry hauled in 12 receptions for 246 yards and four touchdowns across 10 games with the Saints last season. He'll be extra depth for the Broncos right now, but could find his way to the active roster at some point. For now, fantasy managers can leave Perry on the waiver wire.