McCarthy is considered week-to-week after he sustained a high-ankle sprain during Sunday's 22-6 loss to the Falcons, Ian Rapoport of NFL Network reports.

Not long after coach Kevin O'Connell revealed Monday that McCarthy showed up to team facilities with a sore ankle that was deemed a sprain, Rapoport and Tom Pelissero of NFL Network are reporting that the injury may require some time on the sideline. McCarthy didn't fare well in Week 2, completing 11 of 21 passes for 158 yards, no touchdowns and two interceptions, turning five carries into 25 yards and losing one of his three fumbles. O'Connell also told Alec Lewis of The Athletic that Minnesota will get backup QB Carson Wentz ready for Sunday's game against the Bengals in the event McCarthy eventually is inactive.

Coach Kevin O'Connell said Monday that McCarthy has a sprained ankle, and it's unclear if he'll be available Sunday against the Bengals, Alec Lewis of The Athletic reports.

McCarthy had a rough Week 2 after an encouraging Week 1, completing 11 of 21 passes for 158 yards, no touchdowns and two interceptions, turning five carries into 25 yards and losing one of his three fumbles during Sunday's 22-6 loss to the Falcons. If McCarthy ends up missing Week 3, veteran Carson Wentz is in line to step in and lead the Vikings offense.

McCarthy completed 11 of 21 pass attempts for 158 yards, no touchdowns and two interceptions while taking five carries for 25 yards with a lost fumble in Sunday's 22-6 loss to Atlanta.

McCarthy struggled out of the gates like he did for three quarters in his pro debut last week, but he was unable to replicate the fourth-quarter heroics we saw against the Bears in a crushing loss to the Falcons on Sunday Night Football. The 22-year-old looked like a true rookie on the field, throwing two interceptions and putting three balls on the ground (mercifully, losing possession of only one). We have now seen seven poor quarters of play, one eye-opening quarter and a 1-1 record from McCarthy through two starts. This dud will likely steer fantasy managers away from the 2024 first-round pick, but next Sunday's opponent (the Cincinnati Bengals) present a soft fantasy matchup for those buying into a bounce-back performance in Week 3.

Kamara carried the ball 21 times for 99 yards and caught all six of his targets for 21 yards in Sunday's 26-21 loss to the 49ers.

After needing a touchdown to salvage his Week 1 performance, Kamara topped 100 scrimmage yards for the first time in 2025 in Week 2. The veteran RB needed volume to get there though, as his longest run went for only 15 yards. Kamara remains the centerpiece of the Saints' offense under new head coach Kellen Moore, and he could have a big day through the air in Week 3 against a Seahawks defense that has given up 159 combined receiving yards to the Steelers' Jaylen Warren and the 49ers' Christian McCaffrey to begin the season.

Kamara carried the ball 11 times for 45 yards and a touchdown and caught both his targets for 12 yards in Sunday's 20-13 loss to Arizona.

The veteran RB showed he had plenty of juice left in the tank on the Saints' only TD of the game, an 18-yard scamper early in the second quarter, but Kamara otherwise didn't find much running room. Kellen Moore's new offense leaned heavily on the passing game as Spencer Rattler attempted a career-high 46 passes, but that may not be a detriment to Kamara's production given his proven ability as a receiver. He'll look to make an impact again at home Week 2 against the 49ers.

Saints coach Kellen Moore said Wednesday that Kamara will take most of the team's carries, with other running backs ready to step up when there's a chance, Erin Summers of NFL Network reports.

It's what fantasy managers want to hear four days before the season opener, even if there's nothing surprising or unexpected about Moore's quote. Kendre Miller won the No. 2 RB job this summer, but he didn't necessarily do enough to earn a big Week 1 role, more or less defaulting into his depth chart spot after rookie Devin Neal missed much of the summer with a hamstring injury. Miller and Neal could get more involved as the season progresses, but Kamara figures to take well over half of the snaps and touches this Sunday against San Francisco.

Coach Kyle Shanahan noted Monday that Jennings came out of Week 2 action with an ankle injury, Jennifer Lee Chan of NBC Sports Bay Area reports.

Per Nick Wagoner of ESPN.com, Jennings is viewed as day-to-day as this weekend's game against the Cardinals approaches. In Sunday's 26-21 win over the Saints, Jennings parlayed his 87 percent snap share into 5-89-1 line on a team-high 10 targets.

Jennings caught five of 10 targets for 89 yards and a touchdown in Sunday's 26-21 win over New Orleans.

The veteran wideout had a little trouble getting on the same page with new quarterback Mac Jones early in the contest, but the duo connected on a 42-yard TD in the fourth quarter that proved to be the game-winning score. Jennings' final line, and the performance of the 49ers' offense in general without Brock Purdy (toe/shoulder) under center, was very encouraging, and he'll look to keep rolling in a Week 3 clash with the Cardinals.

Jennings (shoulder) is listed as active Sunday at New Orleans, Briana Jeannel of the 49ers' official site reports.

Jennings was forced out of last Sunday's win at Seattle in the fourth quarter due to a left shoulder injury, which capped him to one limited practice during Week 1 prep. Ian Rapoport of NFL Network reported Saturday evening that Jennings was considered a game-time decision for Week 2 action, with a pregame workout to determine whether or not he'd be active. Now that his status has been confirmed for Sunday's contest, Jennings will be available to the 49ers offense, but it remains to be seen what kind of workload he'll be able to handle. He'll also be working with backup QB Mac Jones instead of regular starter Brock Purdy (toe/shoulder), so the outlooks for all San Francisco pass catchers seemingly take a step back in the short term.

Hubbard rushed 10 times for 38 yards and caught five of six targets for 39 yards and a touchdown in Sunday's 27-22 loss to the Cardinals.

Hubbard salvaged another pedestrian rushing performance with a late receiving touchdown in the Panthers' second loss of the season. The 26-year-old starter snuck out of the backfield for a five-yard score in the fourth quarter, also scoring the ensuing two-point attempt for good measure. Hubbard continues to dominate the backfield touches in Carolina, making him a starting level fantasy option heading into next Sunday's tilt against Atlanta.

Hubbard carried the ball 16 times for 57 yards and caught three of five targets for 32 yards and a touchdown in Sunday's 26-10 loss to the Jaguars.

The 26-year-old RB scored the Panthers' only TD late in the fourth quarter, catching the ball in the flat and sprinting down the sideline for a 27-yard score. Hubbard is coming off a career-best 2024 campaign in which he amassed 1,366 yards from scrimmage and 11 total touchdowns, and the offseason addition of Rico Dowdle to the backfield doesn't appear to have impacted his role or touch volume. Hubbard will look to stay productive on the road Week 2 against the Cardinals.

Boswell made all three of his field-goal attempts in the Steelers' loss to the Seahawks on Sunday.

Boswell made a pair of 48-yard field goals in the first half before converting a 45-yard attempt in the fourth quarter. The Steelers scored just one touchdown on the day and successfully went for the two afterward. On the season, Boswell has made all five of his field-goal tries and all four of his extra points.

Boswell went 2-for-2 on field-goal attempts while making all four of his extra-point tries in Sunday's 34-32 win over the Jets.

Boswell made a 56-yard field goal in the second quarter before later connecting on a career-long 60-yard field goal with 1:03 left in the game, giving the Steelers a 34-32 lead. The kicker is considered to be among the most elite players at his position, and he has certainly opened the 2025 campaign on the right foot.

Penix completed 13 of 21 passes for 135 yards with no touchdowns or interceptions in Sunday's 22-6 win over the Vikings.

Penix completed 27 of 42 passes for 298 yards with a touchdown and no interceptions and rushed six times for 21 yards and another score in the Falcons' 23-20 loss to the Buccaneers on Sunday. He also committed a fumble recovered by Atlanta.

Falcons offensive coordinator Zac Robinson said Thursday that Penix, who did not suit up for any preseason action, is "ready to go" for Sunday's regular-season opener against the Buccaneers, D. Orlando Ledbetter of the Atlanta Journal Constitution reports.

Judkins rushed 10 times for 61 yards and brought in all three targets for 10 yards in the Browns' 41-17 loss to the Ravens on Sunday.

Judkins (not injury related) is active for Sunday's game in Baltimore, Daniel Oyefusi of ESPN.com reports.

Judkins (personal), who is officially questionable for Sunday's matchup against Baltimore, will likely be available to play on a limited snap count, but the Browns eventually expect him to settle into a starting role, Ian Rapoport of NFL Network reports.

Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.

Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.

Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.

Legette caught one of eight targets for minus-2 yards in Sunday's 27-22 loss to the Cardinals.

Legette caught three of seven targets for 10 yards in Sunday's 26-10 loss to the Jaguars.