Kansas City Chiefs running back Isiah Pacheco (leg) will undergo surgery in the middle of this week on the fractured fibula that he suffered in the Week 2 win over the Cincinnati Bengals and he's expected to miss at least six weeks, according to sources. NFL Network's Ian Rapoport says that a six- to eight-week timetable is probably a best-case scenario, so the Chiefs will eventually place him on Injured Reserve, which will put him out for at least four games. If doctors find more ligament/tendon damage in Pacheco's leg when they open him up, it could be a longer road back for one of the best young RBs in the NFL. Fantasy managers obviously will want to stash Pacheco everywhere, while rookie Carson Steele immediately becomes one of the top waiver-wire targets this week. Samaje Perine should have an elevated role in KC's backfield as well and is worth a look in deep PPR formats with Pacheco injured.

Philadelphia Eagles rookie wide receiver Johnny Wilson (hamstring), who was listed as questionable on the team's final Week 2 injury report, is officially active for Monday night's contest against the visiting Atlanta Falcons. In his NFL debut in the Week 1 win over the Green Bay Packers in Brazil, Wilson played only 10 offensive snaps and couldn't haul his only target in the game. The 23-year-old sixth-rounder from Florida State could have a bigger role with A.J. Brown (hamstring) inactive, but it's still unlikely to be big enough for him to make an impact for fantasy managers. DeVonta Smith and tight end Dallas Goedert could be leaned on more by quarterback Jalen Hurt on Monday night, with Jahan Dotson also hoping to have a bigger role in the passing attack after not catching his only target in his Eagles debut last week.

Las Vegas Raiders head coach Antonio Pierce is not giving up on struggling running back Zamir White and wants to keep him heavily involved in the team's backfield moving forward. "I'm gonna keep pumping him up. Our goal is to get 20-plus touches with him. That was the goal this week, didn't happen. That's gonna be the goal this week and every week while he's the starting running back and I'm here," Pierce said. White has fallen flat through two weeks as Vegas' lead back in 2024, averaging a career-low 3.1 yards per carry on 22 attempts (68 yards) while catching five passes for only 16 yards. The Raiders basically abandoned the run in the Week 2 upset win over the Ravens, and it was concerning that backup Alexander Mattison vultured a touchdown. White is still the Raiders' go-to back, but volume could be a concern all year long. The good news is he has a smash Week 3 spot against the Carolina Panthers.

San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) suffered a calf strain in the Week 2 loss to the Minnesota Vikings on Sunday and will be forced to miss a couple of weeks. It comes as a surprise after Samuel had eight catches (10 targets) for 110 receiving yards while also carrying the ball twice for 10 yards. With both Samuel and All-Pro running back Christian McCaffrey (Achilles, calf) out for the foreseeable future, San Fran's offense could struggle to put up points heading into a Week 3 divisional matchup against the Los Angeles Rams. Jauan Jennings should step into the WR2 role behind Brandon Aiyuk, who has been slow out of the gates after a lengthy contract hold-in, while tight end George Kittle's fantasy ceiling and floor will now be raised. Samuel's injury makes running back Jordan Mason even more of a lock as a must-start in fantasy lineups going forward.

X-rays came back negative on Los Angeles Chargers quarterback Justin Herbert's lower right leg on Monday, according to head coach Jim Harbaugh. Herbert had his leg rolled up on in the third quarter of the Week 2 win over the Carolina Panthers on Sunday, but he quickly returned to the contest and finished out the day under center. The 26-year-old signal-caller isn't dealing with any structural damage but should be considered day-to-day, nonetheless, heading into a Week 3 matchup against the Pittsburgh Steelers. If by chance the Chargers don't clear Herbert to play this weekend, either Easton Stick or Taylor Heinicke would take over as the starting QB. Herbert has been held under 150 yards passing in both of the first two games of the year in LA's new offense, throwing for three touchdowns and one interception. If he plays in Week 3, he'll remain a low-end QB2 against a tough Steelers defense.

Green Bay Packers rookie MarShawn Lloyd (ankle) said he suffered a sprained ankle in his NFL debut in the Week 2 win over the Tennessee Titans at Lambeau Field on Sunday. Lloyd is walking fine but called himself day-to-day. The 23-year-old has already dealt with three different injuries since training camp that have limited his on-field abilities early in his first year in the NFL. His injury doesn't sound too serious, but it also doesn't mean that Lloyd will be a lock to play in Week 3 against the Tennessee Titans. The third-round selection has a great opportunity to be Green Bay's No. 2 RB behind Josh Jacobs with AJ Dillon (neck) out for the year, but injuries have held him back so far. If Lloyd is limited or out this weekend, Emanuel Wilson will be Jacobs' backup again in Week 3. Lloyd saw six carries and gained 15 yards on the ground while catching one pass for a three-yard gain in his NFL debut on Sunday.

Green Bay Packers head coach Matt LaFleur said that ideally if quarterback Jordan Love (knee) were to play in Week 3 at the Tennessee Titans, Love would practice at least a little since it will have been two weeks without doing anything on the field since injuring his knee in the Week 1 loss in Brazil to the Philadelphia Eagles. The 25-year-old is dealing with an MCL sprain in his left knee and facing an uphill battle to be ready in Week 3. A report surfaced on Sunday morning stating that Love is targeting a return in Week 5 on the road against the Los Angeles Rams, so it would be a surprise if he's back on the field this weekend. Fantasy managers need to prepare for a few more absences. Malik Willis will most likely take on his old team, the Titans, in Week 3 after leading Green Bay to a Week 2 win over the Colts by going 12-for-14 for 122 yards with a touchdown and no interceptions.

New York Jets running back Breece Hall (quadriceps) is dealing with a quadriceps issue on a short turnaround in Week 3 with a contest this Thursday night against the division-rival New England Patriots. The good news for fantasy managers is that Hall was listed as a full practice participant on Monday, so as long as he doesn't suffer some sort of setback the next two days, he should be available as the team's lead RB on Thursday evening. The 23-year-old high-end RB1 in fantasy has delivered the first two weeks with 30 carries for 116 yards and a touchdown on the ground while adding 12 catches (14 targets) for 91 yards and another score through the air. Rookie backup Braelon Allen took some attention away with two TDs on nine touches in the Week 2 win over the Titans, but Hall remains New York's bell-cow back and should be in all starting lineups this Thursday night against the surprising Pats.

When Detroit Lions head coach Dan Campbell was asked about wide receiver Amon-Ra St. Brown's (lower body) injury, he said, "Lower leg. He'll be good. Soft tissue." It's unclear exactly what kind of injury St. Brown is dealing with, but we'll have a clearer picture on Wednesday, the first day of Week 3 practice. The 24-year-old was forced from action at the end of the Week 2 loss to the Tampa Bay Buccaneers in the fourth quarter. Before the injury, St. Brown bounced back in a big way from his quiet season-opening performance with a 11-119-0 line on 19 targets after catching three passes for 13 yards in Week 1. It sounds like the Lions think he'll have a good shot to play in Week 3 against the Arizona Cardinals, but we'll know more later this week. When active, St. Brown is a must-start in fantasy after being taken in the first round in most drafts.

Los Angeles Rams wide receiver Cooper Kupp (ankle) is expected to miss an extended period of time, according to head coach Sean McVay. The star wide receiver is also a candidate to land on injured reserve, knocking him out for at least four games. With Puka Nacua (knee) already on injured reserve, the Rams have Demarcus Robinson, Tyler Johnson, Tutu Atwell, and sixth-round rookie Jordan Whittington healthy at the wide receiver position. Unfortunately, Los Angeles has several players on injured reserve or likely heading there, making fans feel like it's the 2022 season all over again. Matthew Stafford's fantasy value takes a massive hit with his top two playmakers out of the lineup. Fantasy players likely want to avoid starting any Rams player not named Kyren Williams for the foreseeable future.