Arizona Cardinals rookie wide receiver Marvin Harrison Jr. is a flex play with great potential in Week 16. He and the Cardinals will travel to Carolina to face a defense that ranks 16th in fantasy points allowed to opposing receivers. Harrison Jr. has been boom or bust all season, and this week, he's presented with an opportunity to boom. He has been somewhat touchdown-dependent for fantasy production this season, and he will be facing a defense that has allowed the most passing touchdowns in the NFL. Despite not fully living up to the high expectations that come with being a top-five pick to this point, he has received over 90 targets this season and will be involved in Sunday's game plan. Harrison Jr. should be considered a flex play this week, with managers trusting him in their lineups.

Las Vegas Raiders wide receiver Tre Tucker hasn't made much of an impact this season, but he has a chance to have a solid day against one of the NFL's worst pass defenses. Vegas will take on the Jacksonville Jaguars in Week 16, who allow a ludicrous 7.9 yards per pass attempt to opposing teams this season. For context, the gap between JAX and the second-worst team, the Dallas Cowboys, is 0.6 yards. That's the same as the gap between the Cowboys and the 17th ranked pass defense. So the Jags are not only the worst in the league at stopping passers, they're worse by a long shot. With QB1 Aidan O'Connell (knee) expected to return, we could see a few plays where Tucker beats the soft defense deep and AOC chucks it to him downfield. That's worth taking a shot on in very deep fantasy football leagues.

Las Vegas Raiders tight end Jakobi Meyers will face what is easily his softest matchup of the season in Week 16, when the Raiders face the Jacksonville Jaguars. The opposing team has a patented Swiss-cheese secondary, without much cheese and with mostly holes. They're the worst team at defending against wide receivers in the league, and with quarterback Aidan O'Connell returning from an injury, it's a smash spot for Meyers. He's one of the more underrated WRs in the league, probably because he's been on bad offenses his whole career outside of his rookie season. His upside in PPR fantasy football leagues is massive this week, and he should be started in all of them. He was cleared from the injury report, so he's healthy and ready to go. Don't leave him on your benches.

Las Vegas Raiders tight end Brock Bowers will face the Jacksonville Jaguars in Week 16. They have one of the worst pass defenses in the last 25 years in terms of passing Expected Points Added per play allowed. That statistic attempts to measure how impactful each play is for the opposing offense. JAX thus allows a ton of big and crucial plays, and does that often. With the team's QB1, Aidan O'Connell (knee) set to return from injury, Bowers will have his preferred signal-caller back in the lineup, and should be fed a healthy dose of targets. This will be another chance for the stellar rookie to shine, and fantasy managers should not leave him out of their lineups in any leagues with tight end slots in starting lineups. He should be started in all leagues this week, as he's primed for a monster game.

The Las Vegas Raiders will take on the Jacksonville Jaguars in Week 16 in what is an easy matchup for running backs in fantasy. Raiders running back Ameer Abdullah will probably split volume with RB Alexander Mattison (neck), and Abdullah presents the more interesting option in fantasy football, since he seems to have more pass-catching upside. The 31-year old rushed three times for just eight yards in Week 15, but caught all seven of his targets for 58 yards and a touchdown. JAX has one of the league's most porous defenses. These factors make the 10th-year pro an intriguing option in deeper PPR leagues as an RB3/FLEX, but starting anyone from this backfield in fantasy football carries plenty of risk.

Las Vegas Raiders running back Alexander Mattison (neck) is expected to play in Week 16, when his team will take on the Jacksonville Jaguars. We're just a few games away from finally wrapping up the rollercoaster of misery that has been the Raiders backfield in 2024. With RB Zamir White (quad) still on injured reserve and Sincere McCormick (ankle) out for the season, it looks like Mattison will split touches with fellow RB Ameer Abdullah. It's hard to say which one will out-snap the other, but having watched the Raiders this season, it will probably be some kind of committee. We don't expect Mattison to have a ton of fantasy value, as it appears Abdullah is the better pass-catcher, and neither will have a ton of TD upside. The former Minnesota Viking should probably be left on the bench.

New York Giants tight end Daniel Bellinger heads into Week 16 against the Atlanta Falcons looking to build on steady production as the team's lone starting tight end since Theo Johnson's season-ending injury. Over the past two games, Bellinger has tallied eight receptions on 10 targets for 80 yards, averaging 10 yards per catch but has yet to find the end zone. The Falcons' defense has been tough on tight ends recently, ranking 4th in fewest fantasy points allowed to the position over the past four weeks. However, Atlanta's overall struggles against the pass (225.9 yards allowed per game, 27 passing touchdowns surrendered) leave a glimmer of upside for Bellinger, giving the Giants hope in favorable game scripts.

New York Giants wide receiver Wan'Dale Robinson enters Week 16 against the Atlanta Falcons looking to improve on a rocky performance in last week's loss to the Ravens, where he posted four receptions on nine targets for 38 yards. Robinson has been a reliable short-yardage option this season with 71 receptions on 111 targets but averages just 7.4 yards per catch. The Falcons' defense, ranked 27th in fantasy points allowed to wide receivers over the past four weeks, presents an opportunity for Robinson to exploit, particularly in PPR formats. While his lack of big-play ability caps his ceiling, Robinson's volume and the Falcons' struggles on defense (24.4 points allowed per game) might give him an opportunity for a decent game. Robinson was a limited participant in Wednesday's practice (shoulder), but he fully participated on Thursday and Friday.

New York Giants running back Devin Singletary could be in line for an expanded role in Week 16 against the Atlanta Falcons with starter Tyrone Tracy Jr. questionable due to an ankle injury. Singletary has been a steady, if unspectacular, contributor this season with 382 rushing yards, 4 touchdowns, and a 3.9 YPC average, earning 6.93 fantasy points per game. While the Falcons' run defense ranks 13th in yards allowed (116.7 per game) and has given up only seven rushing TDs all season, they've tightened up lately, ranking 6th in fewest RB fantasy points allowed over the past four weeks. Singletary's volume could make him a viable flex play, but his lack of explosiveness and Atlanta's improving defense temper expectations.

Indianapolis Colts running back Jonathan Taylor has 21 or more carries in four of the last five contests with virtually no competition for touches from the other running backs on the team. That is, except for Anthony Richardson who has scored four times on the ground over the last four weeks while Taylor hasn't scored via the rush since Week 8. The 25-year-old nearly had one last week but dropped the ball in celebration before crossing the goal line, resulting in a lost fumble instead. Expect the former second-round draft pick to get a healthy dose of touches again in Week 16 against Tennessee, especially given how good the Titans' pass defense has been, allowing the fifth-fewest fantasy points per game to opposing receivers compared to a rush defense yielding the 13th-most points to opposing backs. The fifth-year pro falls to a high-end RB2 in this week's matchup, who should get plenty of work and comes with RB1 upside if he's able to find the end zone.