Mahomes completed 16 of 29 pass attempts for 187 yards, one touchdown and one interception while taking seven carries for 66 yards and another score in Sunday's 20-17 loss to the Eagles.

Mahomes and the Chiefs dropped to 0-2 on the year after suffering a loss at the hands of the team that embarrassed them in Super Bowl LIX last season. The final score was much closer this time around, but Philadelphia's defense held the superstar QB in check statistically. Mahomes continues to spread the ball around with top wideouts Rashee Rice (suspension) and Xavier Worthy (shoulder) out of action, dialing up nine different targets Sunday after completing passes to seven different receivers in last week's loss. Mahomes is going to continue to have to do the heavy lifting for Kansas City's offense ahead of a Week 3 matchup against the New York Giants on Sunday Night Football.

Mahomes completed 24 of 39 passes for 258 yards with one touchdown and no interceptions and added six rushes for 57 yards and another score in the Chiefs' 27-21 loss to the Chargers on Friday night. He also recovered a fumble.

Mahomes quickly lost his most explosive playmaker when Xavier Worthy went down with a shoulder injury just four plays into the game. The two-time MVP battled throughout the rest of the contest while repeatedly leading the Chiefs from behind, and he offered some hope with an 11-yard touchdown run and 37-yard scoring strike to Travis Kelce in the third and fourth quarter, respectively. In the absence of Worthy, Mahomes recorded completions to seven different targets, focusing the bulk of his attention on Hollywood Brown (10-99-0) and JuJu Smith-Schuster (5-55-0), who were the targets on 21 of his pass attempts. Following this season-opening stumble, Mahomes and the Chiefs will have to quickly turn their focus to a Super Bowl LIX rematch with the Eagles at Arrowhead Stadium in a Week 2 matchup on Sunday, Sept. 14.

Gainwell rushed the ball five times for 20 yards in Sunday's 31-17 loss to the Seahawks. He added three receptions on five targets for 16 yards.

Gainwell was out-touched 18-8 by Jaylen Warren, settling into a change-of-pace role in the Pittsburgh offense. Gainwell's most notable carry came late in the third quarter when he spelled Jaylen Warren near the goal line, but he was stuffed at the four-yard line. Gainwell will likely struggle to get enough volume to be fantasy relevant in most formats, particularly if Kaleb Johnson is able to emerge in the offense as the season progresses.

Gainwell rushed seven times for 19 yards while securing three of four targets for four yards during Sunday's 34-32 win over the Jets.

While rookie Kaleb Johnson drew plenty of buzz during training camp and preseason action as a complementary back alongside Jaylen Warren, Gainwell was on the field for 54 percent of the Steelers' offensive snaps in Sunday's regular-season opener, while Johnson played just two offensive snaps. Gainwell's playing time was encouraging, but he was inefficient with his opportunities. As long as Pittsburgh's backfield remains relatively healthy, it seems unlikely that the 26-year-old will have much fantasy upside in 2025, and it wouldn't be surprising to see Johnson take some of Gainwell's snaps as the season progresses.

Diggs caught four of five targets for 32 yards in Sunday's 33-27 win over the Dolphins.

Diggs tied Rhamondre Stevenson for the team lead in targets but finished third on the Patriots in receiving yards behind Stevenson (88) and Austin Hooper (38). Drake Maye spread the ball out to nine different receivers, and New England's pair of touchdowns through the air went to Mack Hollins and Kayshon Boutte. Diggs is the top option in New England's wide receiver room, but that role doesn't always command significant volume in a Patriots offense predicated on runs and quick passes. Diggs could see a lot of star cornerback Jalen Ramsey in Week 3 against the Steelers, which will make it difficult for the veteran wide receiver to pick up the pace.

Diggs secured six of seven targets for 57 yards in the Patriots' 20-13 loss to the Raiders on Sunday.

Making his team debut and suiting up for his first taste of game action since Week 8 of last season with the Texans, Diggs finished tied for the team lead in receptions while checking in second in targets. While nothing spectacular from a fantasy perspective, Diggs' numbers were encouraging considering it was his first experience working with quarterback Drake Maye in a game setting, and it appears evident he'll be a key target for the second-year signal-caller moving forward. Diggs next takes aim at a defense he's highly familiar with from his days with the Bills, that of the Dolphins, in a Week 2 road matchup next Sunday.

Ferguson caught nine of 12 targets for 78 yards in Sunday's 40-37 overtime win over the Giants.

The tight end led the Cowboys in target volume during a wild seesaw affair and tied CeeDee Lamb for the team lead in receptions, although Lamb out-paced him in yards with 112. Ferguson has re-established himself as the main security blanket for Dak Prescott, and while he's still looking for his first touchdown since he caught three against Green Bay in the wild-card round of the 2023 season, he's delivered a 14-101-0 line on 18 targets through the first two games of the current campaign. Ferguson could hit paydirt in Week 3 against a Bears defense that just gave up a TD to the Lions' Brock Wright, one of five touchdowns thrown by Jared Goff in a 52-21 rout.

Ferguson brought in five of six targets for 23 yards in the Cowboys' 24-20 loss to the Eagles on Thursday night.

Ferguson finished second in receptions on the Cowboys to CeeDee Lamb and third in receiving yards, although the latter total was a reflection of a low-volume passing night for Dallas. Nevertheless, it was encouraging to see Ferguson as Dak Prescott's second-favorite target on the night, as it was a reminder of the chemistry between the two that was nullified by Prescott's season-ending hamstring avulsion in Week 9 of last season. Ferguson could remain similarly busy during the Cowboys' Week 2 home opener against the Giants on Sunday, Sept. 14.

Johnston caught just three of his seven targets for 71 yards and a touchdown in the 20-9 win over the Raiders on Monday.

Johnson had multiple critical drops in the first quarter, but for a second consecutive week the 24-year-old once again connected with Justin Herbert on a beautiful frozen rope, this time for a 60-yard touchdown that proved to be all the scoring necessary to beat the Raiders. The 2023 first-round pick did tie for the team high with seven targets, but unlike Keenan Allen and Ladd McConkey, the majority of Johnston's targets appeared to be scripted and don't necessarily indicate a potential bump in volume on a week-to-week basis.

Johnston finished with five receptions (on seven targets) for 79 yards and a pair of touchdowns in Friday's 27-21 win over the Chiefs.

Johnston looked like a fantasy stud in Brazil after cashing in on two of Justin Herbert's trio of touchdown passes. The third-year wideout has had his shares of ups and downs, but this is the kind of performance the Chargers had in mind when they selected Johnston in the first round of the 2023 NFL Draft. It is worth noting that both Keenan Allen (7-68-1) and Ladd McConkey (6-74-0) finished with more targets and receptions in Friday's win. That said, if the Chargers offense continues to air out it out like we saw against the Chiefs, then all three starting receivers theoretically could eat this season. Johnston appears to be a priority addition ahead of next Monday's matchup against the Raiders.

Wilson completed 30 of 41 passes for 450 yards and three touchdowns with one interception in Sunday's 40-37 overtime loss to the Cowboys. He added 23 yards on three carries.

Giants coach Brian Daboll said Monday that Wilson will start Sunday on the road against Dallas in Week 2, Patricia Traina of SI.com reports.

Wilson completed 17 of 37 passes for 168 yards, no touchdowns and no interceptions in Sunday's 21-6 loss to the Commanders. He also rushed eight times for 44 yards.

Davis rushed nine times for 24 yards in Sunday's 30-10 win over the Jets.

Davis rushed once for two yards and reeled in his lone target for minus-one yard in Sunday's 41-40 win over the Ravens.

Sanders carried the ball five times for 15 yards and a touchdown and caught both his targets for four yards in Sunday's 40-37 overtime win over the Giants.

Sanders rushed four times for 53 yards, caught his only target for minus-3 yards and lost a fumble in Thursday's 24-20 loss to the Eagles.

Sanders, Javonte Williams and FB Hunter Luepke will serve as the Cowboys' backfield options Thursday in Philadelphia with rookie Jayden Blue (coach's decision) inactive, Calvin Watkins of The Dallas Morning News reports.

Shaheed caught four of five targets for 52 yards and a touchdown in Sunday's 26-21 loss to the 49ers.

Shaheed caught six of nine targets for 33 yards in Sunday's 20-13 loss to the Cardinals.

Kincaid caught four of six targets for 37 yards in Sunday's 30-10 win over the Jets.

Kincaid caught all four of his targets for 48 yards and a touchdown in Sunday's 41-40 win over the Ravens.