Mahomes completed 16 of 29 pass attempts for 187 yards, one touchdown and one interception while taking seven carries for 66 yards and another score in Sunday's 20-17 loss to the Eagles.

Mahomes and the Chiefs dropped to 0-2 on the year after suffering a loss at the hands of the team that embarrassed them in Super Bowl LIX last season. The final score was much closer this time around, but Philadelphia's defense held the superstar QB in check statistically. Mahomes continues to spread the ball around with top wideouts Rashee Rice (suspension) and Xavier Worthy (shoulder) out of action, dialing up nine different targets Sunday after completing passes to seven different receivers in last week's loss. Mahomes is going to continue to have to do the heavy lifting for Kansas City's offense ahead of a Week 3 matchup against the New York Giants on Sunday Night Football.

Mahomes completed 24 of 39 passes for 258 yards with one touchdown and no interceptions and added six rushes for 57 yards and another score in the Chiefs' 27-21 loss to the Chargers on Friday night. He also recovered a fumble.

Mahomes quickly lost his most explosive playmaker when Xavier Worthy went down with a shoulder injury just four plays into the game. The two-time MVP battled throughout the rest of the contest while repeatedly leading the Chiefs from behind, and he offered some hope with an 11-yard touchdown run and 37-yard scoring strike to Travis Kelce in the third and fourth quarter, respectively. In the absence of Worthy, Mahomes recorded completions to seven different targets, focusing the bulk of his attention on Hollywood Brown (10-99-0) and JuJu Smith-Schuster (5-55-0), who were the targets on 21 of his pass attempts. Following this season-opening stumble, Mahomes and the Chiefs will have to quickly turn their focus to a Super Bowl LIX rematch with the Eagles at Arrowhead Stadium in a Week 2 matchup on Sunday, Sept. 14.

Kupp caught seven of nine targets for 90 yards in Sunday's 31-17 win over the Steelers.

Kupp bounced back from a two-catch Seahawks debut but once again finished second on the team in receiving yards behind Jaxon Smith-Njigba. Kupp and JSN combined for 19 targets while no other teammate had more than four, but Sam Darnold's first two touchdown passes of the season went to Tory Horton and AJ Barner. Up next for Seattle's new-look passing game is a Week 3 home game against the Saints.

Kupp brought in two of three targets for 15 yards in Sunday's 17-13 loss to the 49ers.

Kupp struggled to establish himself in Seattle's new-look offense, finishing a distant second behind Jaxon Smith-Njigba (9-124-0) in overall production. The 32-year-old Kupp may not be his former MVP self, but the fact he still finished second in targets bodes well for his prospects in games with higher passing volume than the 23 attempts Seattle amassed Sunday. For now, Kupp's fantasy value may be limited to deeper formats for next week's contest against the Steelers.

Kamara carried the ball 21 times for 99 yards and caught all six of his targets for 21 yards in Sunday's 26-21 loss to the 49ers.

After needing a touchdown to salvage his Week 1 performance, Kamara topped 100 scrimmage yards for the first time in 2025 in Week 2. The veteran RB needed volume to get there though, as his longest run went for only 15 yards. Kamara remains the centerpiece of the Saints' offense under new head coach Kellen Moore, and he could have a big day through the air in Week 3 against a Seahawks defense that has given up 159 combined receiving yards to the Steelers' Jaylen Warren and the 49ers' Christian McCaffrey to begin the season.

Kamara carried the ball 11 times for 45 yards and a touchdown and caught both his targets for 12 yards in Sunday's 20-13 loss to Arizona.

The veteran RB showed he had plenty of juice left in the tank on the Saints' only TD of the game, an 18-yard scamper early in the second quarter, but Kamara otherwise didn't find much running room. Kellen Moore's new offense leaned heavily on the passing game as Spencer Rattler attempted a career-high 46 passes, but that may not be a detriment to Kamara's production given his proven ability as a receiver. He'll look to make an impact again at home Week 2 against the 49ers.

Saints coach Kellen Moore said Wednesday that Kamara will take most of the team's carries, with other running backs ready to step up when there's a chance, Erin Summers of NFL Network reports.

It's what fantasy managers want to hear four days before the season opener, even if there's nothing surprising or unexpected about Moore's quote. Kendre Miller won the No. 2 RB job this summer, but he didn't necessarily do enough to earn a big Week 1 role, more or less defaulting into his depth chart spot after rookie Devin Neal missed much of the summer with a hamstring injury. Miller and Neal could get more involved as the season progresses, but Kamara figures to take well over half of the snaps and touches this Sunday against San Francisco.

Maye completed 19 of 23 passes for 230 yards and two touchdowns while rushing 10 times for 31 yards and a touchdown in Sunday's 33-27 win over the Dolphins.

Maye completed 30 of 46 passes for 287 yards with a touchdown and an interception and added four rushes for 11 yards in the Patriots' 20-13 loss to the Raiders on Sunday. He also committed a fumble recovered by New England.

Penix completed 13 of 21 passes for 135 yards with no touchdowns or interceptions in Sunday's 22-6 win over the Vikings.

Penix completed 27 of 42 passes for 298 yards with a touchdown and no interceptions and rushed six times for 21 yards and another score in the Falcons' 23-20 loss to the Buccaneers on Sunday. He also committed a fumble recovered by Atlanta.

Falcons offensive coordinator Zac Robinson said Thursday that Penix, who did not suit up for any preseason action, is "ready to go" for Sunday's regular-season opener against the Buccaneers, D. Orlando Ledbetter of the Atlanta Journal Constitution reports.

Milroe (coach's decision) is inactive but will serve as the Seahawks' emergency third-string quarterback against the Steelers on Sunday, Brady Henderson of ESPN.com reports.

Milroe rushed once for one yard in Sunday's 17-13 loss to the 49ers.

Hunt took eight carries for 31 yards and caught his only target for three yards in Sunday's 20-17 loss to the Eagles.

Hunt rushed five times for 16 yards and secured two of three targets for 10 yards during the Chiefs' 27-21 loss to the Chargers on Friday night.

Palmer caught two of three targets for 47 yards in Sunday's 30-10 win over the Jets.

Palmer caught five of nine targets for 61 yards in Sunday's 41-40 win over the Ravens.