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Philadelphia Eagles running back Saquon Barkley will go on the road to take on the Los Angeles Rams in Week 12. The 27-year-old tallied nearly 200 total yards against the Washington Commanders last week and found the end zone twice. Washington was a solid matchup heading into last week, but the Rams present a bit more of a challenge. Los Angeles has allowed just six rushing touchdowns this year and they allow the 11th-fewest fantasy points per game. With that said, the Eagles are without wide receiver DeVonta Smith and have been the run-heaviest offense in the NFL as of late. Barkley is matchup-proof and is a no-brainer must-start in Week 12.

Detroit Lions running back David Montgomery heads into a favorable Week 12 matchup against the Indianapolis Colts, fresh off a two-touchdown performance in Week 11. Montgomery rushed 15 times for 75 yards and two scores while adding 20 yards on three receptions in Detroit's dominant 52-6 win over the Jaguars. With 10 touchdowns in 10 games, Montgomery remains the Lions' primary red-zone option, ranking ninth in red-zone touches and fourth in total touchdowns this season. Montgomery has been one of the most consistent backs in fantasy, finishing outside the top 24 just once this year. The Colts rank 28th against the run, allowing the sixth-most rushing yards per game and the second-most yards after contact per attempt. Expect Montgomery to capitalize on a positive game script and deliver another reliable performance for fantasy managers in Week 12.

Miami Dolphins running back Alec Ingold (calf) has been designated as questionable for the team's matchup against the New England Patriots this Sunday. It's the third consecutive week the sixth-year veteran has been given the questionable tag. Despite logging three limited practice sessions in Weeks 10 and 11, Ingold was ultimately inactive for the ensuing two contests. Miami hopes history doesn't repeat itself, as he was yet again limited all week leading up to their Week 12 home tilt. Last Sunday, the Dolphins compensated for the loss of Ingold by deploying tight ends Jonnu Smith and Julian Hill more frequently, and they may do so again if the veteran is forced to miss another game.

Indianapolis Colts wide receiver Adonai Mitchell made a splash in Week 10 without Michael Pittman Jr. (six catches, 71 yards) but reverted to his status as the No. 4 receiver in Week 11 (one catch, 33 yards) and will assume that role again in Week 12 with a fully healthy receiving corps. The 22-year-old has speed and uses it for deep targets, sitting just outside the top 10 WRs in aDOT (14.2). However, without volume and with a notoriously inaccurate QB, the former second-round draft pick makes for a very risky fantasy play. If you're looking for a reason to use him, there is a strong possibility that as seven-point underdogs, the Colts will be trying to keep pace with the Lions for the entire game, which could mean a few additional deep targets for the rookie wideout. The product out of the University of Texas is a WR5/6 dart throw, even in a week with six teams on bye.

Detroit Lions wide receiver Amon-Ra St. Brown heads into a Week 12 matchup against the Indianapolis Colts as one of the most reliable WR1 options in fantasy football. St. Brown is coming off an elite performance in Week 11, catching all 11 targets for 161 yards and two touchdowns, extending his touchdown streak to eight consecutive games. He ranks as the WR2 on the season, trailing only Ja'Marr Chase in fantasy points. St. Brown has exceeded 100 receiving yards in three games this season and thrives against zone defenses like the Colts, who rank 26th against the pass. Fantasy managers should continue to trust him as an elite WR1 option.

Indianapolis Colts wide receiver Alec Pierce owns the largest percentage of his team's air yards (28.15%), but not only that, he leads the entire NFL in average depth of target (21.25) -- and it isn't even close. The downside for him is that he's received just four targets or less in eight of 11 contests. On the bright side, the 24-year-old usually makes the most of it, leading his team in reception yards (although Josh Downs is not far behind despite playing two fewer games) while recording a 30-plus yard reception in five of 11 weeks. Pierce figures to earn his usual share of deep shots in Week 12's matchup against the Lions, especially if the Colts -- who are seven-point underdogs -- find themselves trailing late in the game. The former second-round draft pick ranks in the WR5 range this week, but with his four TDs on the season, the third-year pro does possess some upside.

Detroit Lions running back Jahmyr Gibbs heads into Week 12 against the Indianapolis Colts as a consistent RB1 option for fantasy managers. Gibbs has been electric, finishing as the RB6 last week after turning 12 touches into 123 total yards and a touchdown. He's a Top-6 RB in total fantasy points this season and ranks fifth in rushing yards, demonstrating his ability to maximize his opportunities. The Colts present a favorable matchup, ranking 28th against the run while allowing the sixth-most rushing yards per game and the second-most rushing attempts. Gibbs has scored five touchdowns in his last five games and surpassed 100 scrimmage yards six times this season. Working in tandem with David Montgomery, Gibbs remains a dynamic playmaker and should be locked in as an RB1 for Week 12.

Detroit Lions quarterback Jared Goff heads into Week 12 against the Indianapolis Colts riding high after his best performance of the season last week. Goff ranks among the league's best in key metrics, leading all quarterbacks in yards per attempt while sitting second in passer rating and fifth in CPOE. The Colts defense has shown improvement recently but remains vulnerable, allowing the ninth-most completions and eighth-most passing yards per game to opposing quarterbacks. While Indy has tightened up since Week 6, Goff's efficiency and the Lions' offensive weapons should keep him in the mix as a solid QB1 option. With Detroit's potent scoring offense averaging 31.6 points per game, Goff is poised to remain productive for fantasy managers again in Week 12.

Indianapolis Colts wide receiver Michael Pittman Jr. is having a quiet season thus far, but Week 11 gave us hope that he could still manufacture some worthwhile fantasy production with Anthony Richardson under center, garnering a team-high eight targets and turning it into five catches for 46 yards. Week 12 brings a matchup against the Lions in a game that boasts an over/under of 50 points, so there should be a decent amount of scoring on both sides. The Lions have been tough against the run this year but can be beaten through the air, having given up the sixth-most passing yards per game and seventh-most fantasy points to WRs. If this game goes to script, the Colts will be playing catch-up with the Lions throughout, which should mean plenty of targets for the receiving corps. Even though the 6-foot-4 wideout showed up on the injury report this week as he continues to battle through a back issue, he was listed as a full participant all week and has been cleared to play. All of this combined with the fact that six teams are on bye this week make the 27-year-old a low-end WR3 this week.

Seattle Seahawks tight end AJ Barner has enjoyed a few weeks as the starter, but fellow tight end Noah Fant (groin) was a full participant in practice on Friday and is trending toward playing in Week 12 against the Arizona Cardinals. Barner did not do much with his opportunities, but he earned at least four targets in each of his last two games. As a rookie tight end, Barner is better suited as a blocker for now. During his time as a starter, he displayed solid pass-catching chops and escape ability so he could emerge later in his career. If Fant is a surprise inactive on Sunday, then Barner would still not likely deserve much attention in fantasy. His best outing was a 6.7-point game in Week 9 against the Los Angeles Rams. That does not exactly get it done in fantasy. If you have Fant, then pay close attention to Barner just in case you need a last-minute dart throw. Otherwise, Barner should be on waivers.