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San Francisco 49ers wide receiver Deebo Samuel Sr. (wrist/illness) did not practice on Wednesday. Samuel has been battling a wrist injury for a couple of weeks and he was limited to four snaps in Week 7 for what was described as a "pneumonia-like" illness. Samuel was even hospitalized with fluid in his lungs and was released on Tuesday. It sounds like Samuel is back with the team this week which is a good sign that his recovery is going well. Head Coach Kyle Shanahan has remained non-committal on Samuel's status for the weekend. However, the hope is that Samuel will be able to play against the Dallas Cowboys in Week 8. If he can play, then Deebo is in line for a huge workload. None of the 49ers' main weapons practiced on Wednesday. Someone will need to catch passes for this team and should have a good time doing so against a lackluster Cowboys defense. In Samuel's five full games in 2024 he has recorded 335 receiving yards and a touchdown. He also has 51 rushing yards and a touchdown.

San Francisco 49ers tight end George Kittle (foot) did not practice on Wednesday. Kittle has a sprained foot and is considered day-to-day. Veterans with various ailments are often permitted a day off on Wednesdays so Kittle's practice participation will need to be monitored as the weekend approaches. With the 49ers nursing several injuries, they will need all hands on deck. Kittle has been awesome in 2024. He currently sits as the TE2 with 375 receiving yards and five touchdowns. Despite the 49ers' ups and downs this season, Kittle is still on his way to a monster season. The 49ers play the Dallas Cowboys in Week 8 in what should be a high-scoring affair. With so many weapons down for the 49ers, Kittle may literally be the last man standing. Presuming he is able to suit up this weekend, Kittle should be a smash start once again.

Despite the fact that Tennessee Titans wide receiver Calvin Ridley (foot) did not practice on Wednesday, Paul Kuharsky reports that the expectation is that Ridley will return to practice on Thursday and be good to go for Sunday's Week 8 contest against the Detroit Lions. The 29-year-old pass catcher was only able to haul in three of his team-leading nine targets for 42 yards in last week's blowout loss to the Buffalo Bills with quarterback Mason Rudolph making the start. He just hasn't been able to make much of an impact in a Titans offense that has struggled to move the ball consistently under second-year QB Will Levis (shoulder). Rudolph doesn't give Ridley much more upside heading into his second straight start against Detroit, although Hopkins leaving town in a trade doesn't hurt. Through six games in 2024, Ridley ranks 73rd among wideouts with 6.5 half-PPR points per game.

New Orleans Saints running back Alvin Kamara (hand) revealed on Wednesday that he suffered a broken hand in the Week 5 loss to the Kansas City Chiefs. That's also the same game that quarterback Derek Carr suffered an oblique injury that will cause him to miss a third straight game in Week 8 against the Los Angeles Chargers. Kamara has played the last two games with his hand injury, but the Saints offense has cratered with Carr out, and Kamara has 20 carries for 50 yards (2.50 yards per carry) and a touchdown on the ground during that span. Things won't get any easier for the 29-year-old, who ranks second behind Derrick Henry this year in overall fantasy points for RBs, going into a matchup this Sunday against the Chargers. Kamara has fallen to RB2 territory in fantasy.

Kansas City Chiefs running back Kareem Hunt (hip) is on the Week 8 injury report and was listed as limited in Wednesday's practice. Hunt never appeared to be injured in the Week 7 win over the San Francisco 49ers on Sunday, suggesting he's in no real danger of missing the Week 8 divisional clash against the Las Vegas Raiders. Fantasy managers will still want to keep an eye on his status the rest of the week. If the 29-year-old's status ends up being in question this weekend, rookie Carson Steele and Samaje Perine would split backfield duties for KC in an excellent matchup. Hunt saw 22 carries against San Fran and went for 78 yards and two rushing touchdowns. As long as Isiah Pacheco (leg) remains on Injured Reserve, Hunt should be a must-start in fantasy lineups as long as he's active.

Indianapolis Colts wide receivers Michael Pittman Jr. (back) and Josh Downs (toe) were both not seen at practice on Wednesday. Pittman and Downs were also rested last Wednesday, so as long as they return to practice on Thursday or Friday, it seems likely they'll both be active for Week 8 against the division-rival Houston Texans after they both played in the Week 7 win over the Miami Dolphins. Pittman nearly went on Injured Reserve initially after sustaining a back injury, so it's an injury that he could be playing through for a while. He played 89% of the offensive snaps last Sunday and caught three passes for 63 yards in quarterback Anthony Richardson's return. Downs had just one catch for three yards. Given Richardson's inconsistency as a passer early in his career, both Pittman and Downs figure to be more volatile from a fantasy standpoint.

Philadelphia Eagles tight end Dallas Goedert (hamstring) did not practice on Wednesday, according to Dave Zangaro of NBC Sports Philadelphia. Goedert did not play in last weekend's game due to a hamstring injury he suffered during Week 6. Fantasy managers should continue to monitor his status during the week, as he still has two more opportunities to participate in practice before the weekend. If Goedert is able to play on Sunday, he should be viewed as a low-end TE1 facing a Cincinnati defense that has allowed the 29th-most points to opposing tight ends. If he cannot play, fantasy managers should expect both A.J. Brown and DeVonta Smith to see the vast majority of targets in the Philadelphia air attack.

Seattle Seahawks wide receiver DK Metcalf (knee) will not practice on Wednesday or Thursday, according to Michael-Shawn Dugar of The Athletic. The 26-year-old suffered a knee injury during Sunday's game against the Atlanta Falcons. Metcalf was originally deemed week-to-week but could still suit up this weekend. Fantasy managers should pay close attention to Friday's injury report, as Metcalf will likely carry an injury designation into the weekend. Metcalf has enjoyed a strong start to the campaign and has scored at least 17.0 PPR points in four out of the seven games he has played. If he is able to suit up this weekend, he should be started in all formats as a high-end WR2. If he cannot play, Tyler Lockett and Jaxon Smith-Njigba should see an increase in targets.

New Orleans Saints wide receiver Chris Olave (concussion) was at Wednesday's practice, according to Nick Underhill of the New Orleans Football Network. Olave was sidelined last week with a concussion. This is a great sign to see him return to practice, however, the 24-year-old will need to pass concussion protocol before he can officially return to game action. Fantasy managers should continue to monitor his status throughout the week. If Olave is able to return this weekend, he should be started in all formats as a WR2 facing a tough Los Angeles Chargers defense that has allowed the second-fewest PPR points to opposing wideouts. Rookie quarterback Spencer Rattler will make another start as well, which will make Olave more volatile.

San Francisco 49ers wide receiver Brandon Aiyuk (knee) was officially placed on Injured Reserve on Wednesday, according to Adam Schefter of ESPN. The 26-year-old suffered a torn ACL and MCL in last Sunday's game against the Kansas City Chiefs and will miss the remainder of the 2024 season. As a result, Deebo Samuel Sr. (illness), Jauan Jennings (hip) and rookie Ricky Pearsall are expected to lead the wide receiver room for the remainder of the season. However, Samuel left last game early due to pneumonia and is in danger of missing Sunday's game against the Dallas Cowboys, which could open up a larger role for Jennings, Pearsall and rookie Jacob Cowing. Fantasy managers looking to add a receiver with upside for high volume should check their waiver wire for both Jennings and Pearsall, as they should have a profound role in the offense going forward.