San Francisco 49ers running back Christian McCaffrey (calf, Achilles) was placed on the injured reserve on Saturday. This news comes after McCaffrey was sidelined for the season opener due to Achilles tendinitis and a calf strain. He'll miss at least the next four games after being placed on the injured reserve, but he could be out longer than that. Ian Rapoport believes it could take up to six weeks for McCaffrey to heal from his Achilles tendinitis. Possibly, McCaffrey is able to play through the issue after his stint on the injured reserve, but fantasy managers should prepare for him to miss up to six weeks. In his absence, Jordan Mason figures to be the lead back and should be rostered in just about every fantasy format after his showing in Week 1.

The San Francisco 49ers are placing running back Christian McCaffrey (calf/Achilles tendinitis) on Injured Reserve today, aiming for him to fully recover from his Achilles tendinitis over the next four games. McCaffrey missed most of training camp and did not play in the preseason due to a calf strain, which head coach Kyle Shanahan disclosed on August 6. The reigning AP Offensive Player of the Year, McCaffrey led the league last season in touches (339), rushing yards (1,459), yards from scrimmage (2,032), and scrimmage touchdowns (21). The earliest he can return is October 10th against Seattle on Thursday Night Football. In his absence, Jordan Mason stepped up as the 49ers' RB1, delivering a standout performance with 152 yards and a touchdown on 29 touches. While Mason's impressive showing provides some reassurance, it's important to note that McCaffrey's unique skill set and versatility are irreplaceable. Mason will serve as an RB1 until McCaffrey's return, and this situation underscores the importance of rostering your running back's handcuffs to prepare for potential injuries.

Updating a previous report, the San Francisco 49ers may place running back Christian McCaffrey (Achilles, calf) on the Injured Reserve on Saturday, which would rule him out for at least the next four games. The Niners ruled McCaffrey out for Week 2 versus the Minnesota Vikings this Sunday after he was unable to practice on Friday. CMC suffered a calf strain early in training camp, but he's also dealing with Achilles tendinitis, which is why he sat out the season-opening win over the New York Jets on Monday night. This is pretty much a worst-case scenario for fantasy managers that took McCaffrey at the top of their drafts, as he's now likely to miss at least the first month of the season. CMC obviously needs to be stashed everywhere. Jordan Mason, who went off as the team's RB1 in Week 1 in place of McCaffrey, now sees his fantasy stock rise even more. He's rostered in 82% of Yahoo leagues right now.

Los Angeles Rams wide receiver Puka Nacua (knee) could miss between five and seven weeks depending on how fast and how well his PCL recovers, according to ESPN's Adam Schefter. Nacua is coming off a historic rookie season and caught four passes for 35 yards early in last week's season opener. Now, he'll be forced to miss some time while Cooper Kupp commands an even greater share of targets on offense. Tight end Colby Parkinson and receivers Demarcus Robinson and Tyler Johnson should help fill the void left by Nacua heading into a pivotal stretch of games.

When asked if the team's Week 6 bye will help get Los Angeles Rams wide receiver Puka Nacua (knee), and offensive linemen Steve Avila (knee) and Joe Noteboom (ankle) back after only missing the required four games while on Injured Reserve, head coach Sean McVay said, "They each have unique injuries that as of right now could keep them out longer than that." The Rams officially placed all three players on IR on Wednesday, meaning they have to sit out Weeks 2-5. The 23-year-old Nacua will have an extra week to recover because of the team's bye, but it sounds like he may not even be ready for Week 7 against the Raiders due to a PCL sprain in his right knee that he suffered in the Week 1 loss to the Lions. WR1 Cooper Kupp is going to eat with Nacua sidelined, while Demarcus Robinson and Tyler Johnson will also be much more involved in the passing game, as well as tight end Colby Parkinson.

The Los Angeles Rams officially placed wide receiver Puka Nacua (knee) on Injured Reserve on Wednesday. The team announced early in the week that he would go on IR, but it is now official, and he must sit out at least the next four games. It's an unfortunate development for Nacua and his fantasy managers who took him in the first or second round of preseason fantasy drafts following a 105-catch, 1,486-yard, six-touchdown season as a rookie. He will be first eligible to return following Los Angeles' Week 6 bye leading up to the matchup with the Las Vegas Raiders in Week 7. While he's out, Cooper Kupp, who saw 21 targets in Week 1, should continue to dominate targets. However, wideouts Demarcus Robinson and Tyler Johnson and tight end Colby Parkinson will see increased opportunities. In deep leagues, Tutu Atwell might be worth stashing.

Tampa Bay Buccaneers wide receiver Mike Evans was unable to carry his Week 1 success into Sunday's game against the Detroit Lions. The veteran wideout finished with 61 yards and two touchdowns in the season opener. However, he was only able to haul in three receptions for 42 yards in the Week 2 win over the Detroit Lions. Evans and quarterback Baker Mayfield weren't on the same page here as Evans only hauled in half of his targets. Fellow wideout Chris Godwin had a much better performance with over 100 yards on Sunday. Evans should be fine and remain on the WR1 radar for a favorable matchup against the Denver Broncos next week.

Tampa Bay Buccaneers wide receiver Mike Evans had seemingly no issues as he tore apart the Washington Commanders defense last week. The veteran wideout hauled in five of his six targets for 61 yards and two touchdowns in the blowout win. Evans has been one of the most reliable wideouts over the last decade and that doesn't look like it's going to change anytime soon. He will get a tougher challenge in Week 2 against the Detroit Lions defense. However, the Lions secondary still has holes, so Evans should be able to continue producing WR1 numbers in Week 2.

Tampa Bay Buccaneers wide receiver Mike Evans had seemingly no issues during Sunday's game against the Washington Commanders. The veteran wideout has been one of the most consistent players throughout his career. That trend continued during Sunday's game as Evans hauled in five receptions for 61 yards and two touchdowns in the win. To be fair, the Commanders secondary is shaky, but Evans took advantage of that with two fairly easy touchdowns. Fantasy managers should be able to plug Evans in as WR1 on a weekly basis going forward.

New Orleans Saints quarterback Derek Carr torched the Dallas defense in Week 2's 44-19 blowout win. Carr has been on fire to start the season, quarterbacking the team's hottest offense to an average of 45.5 points per game. Carr only had to throw 16 passes in the win, completing 11 for 243 yards and two touchdowns with an interception. He also rushed once for one yard. The veteran quarterback is now firmly in the streaming conversation as New Orleans gears up for next Sunday's game against Philadelphia.

New Orleans Saints quarterback Derek Carr (illness) was ill on Sunday morning but will play against the Dallas Cowboys on Sunday, according to a note on NFL.com's official injury report tracker. Carr was added to the injury report Sunday but did not have any designation, which is a good sign that he won't have any limitations in Week 2. The quarterback faces a tough matchup in the form of the Dallas Cowboys, but he's coming off a big performance against the Panthers and figures to maintain some QB2 appeal this weekend. He's a fine option in deeper two-quarterback leagues.

New Orleans Saints quarterback Derek Carr was unconscious in Week 1, completing 19-of-23 passes for three touchdowns. However, the veteran faces a much tougher opponent this week in a Dallas defense that shut down Cleveland in Week 1. The tough matchup makes it hard to consider Carr as a starting option even in two-quarterback formats. He should not be started in any one quarterback format this week. Carr and the Saints take on Dallas in the early slate on Sunday.

Miami Dolphins running back Raheem Mostert (chest) is practicing on Wednesday after missing last week's Thursday Night Football contest against the Buffalo Bills with a chest injury. The 32-year-old had a poor showing in Week 1 against the Jacksonville Jaguars, totaling just 19 yards on seven touches. Miami's backfield is already becoming tricky to navigate, and the fantasy ceiling of all the Miami backs could take a hit while Tua Tagovailoa (concussion) is sidelined. Sophomore running back De'Von Achane remains a must-start option, but Mostert is likely to see fewer red-zone and goal-line opportunities over the next handful of games after he scored 21 touchdowns in 2023. If Mostert is active this week, consider him a shaky flex play for the Week 3 contest against the Seattle Seahawks.

Miami Dolphins running back Raheem Mostert (chest) will not play on Thursday Night Football against the Buffalo Bills due to a chest injury, but his injury is not expected to keep him out long, and he's unlikely to go on Injured Reserve. A stint on the IR list would mean he would have to miss at least the next four games, so this is good news for his fantasy managers. However, the 32-year-old could only produce 19 yards on seven touches last week against the Jacksonville Jaguars, while De'Von Achane (ankle) posted 100 total yards on 17 touches. It's too early to say Mostert could be regressing, but it's on the table. In his absence, Jeff Wilson Jr. and/or Jaylen Wright will handle touches behind Achane, assuming he's active for Week 2.

Miami Dolphins running back Raheem Mostert (chest) will not play on Thursday Night Football against the Buffalo Bills, according to head coach Mike McDaniel. The 32-year-old missed practice on Monday and Tuesday with a chest injury. Mostert did not have a promising start to the season in Week 1 against the Jacksonville Jaguars, rushing six times for nine yards and catching two passes for 10 yards. De'Von Achane (ankle) was also held out on Monday and Tuesday due to an ankle injury, so the injury concerns in this backfield are already coming to life. McDaniel said Achane's status could be up in the air. If Achane plays, he's a must-start option in all leagues. That said, either or both Jeff Wilson Jr. and rookie Jaylen Wright could see work behind him in Mostert's absence, making them low-end flex plays. If Achane can't suit up, both of Miami's backup running backs are flex dice rolls in leagues of 12 teams or more. Wright was a healthy inactive in Week 1, but he could get involved with injuries already piling up.

Cleveland Browns running back D'Onta Foreman carried the ball 14 times for 42 yards while adding nine yards on one catch in an 18-13 win over the Jacksonville Jaguars in Week 2. Foreman led the Browns in carries just one week after playing only one snap in a loss to the Dallas Cowboys in Week 1. Cleveland appears content to split the backfield work between Foreman and Ford until Nick Chubb (knee) is ready to be activated from injured reserve. For now, Foreman is worth a waiver add in deeper leagues ahead of a Week 3 matchup against the New York Giants.

Denver Broncos wide receiver Courtland Sutton disappointed with just one reception on four targets for 26 yards in the team's Week 2 loss to the visiting Pittsburgh Steelers in Denver on Sunday. After seeing a team-high 12 targets in the season-opening loss to the Seattle Seahawks, Sutton saw just four looks against a strong Steelers defense this weekend and continued his inefficiency working with rookie quarterback Bo Nix. Through two games, the 28-year-old has only five catches for 64 yards on 16 total targets. Sutton should finish the year as the team's most targeted wideout, but right now, fantasy managers shouldn't feel comfortable using him as a WR4/flex on a weekly basis. Look for the Broncos to get Sutton more involved in their Week 3 road matchup against the Tampa Bay Buccaneers next weekend.

Denver Broncos wide receiver Courtland Sutton had a team-high 12 targets and played 91% of the offensive snaps in the Week 1 loss to the Seattle Seahawks, but that led to only four receptions for 38 yards in rookie quarterback Bo Nix's wobbly debut. Sutton is fully expected to lead Denver's wideouts in targets by a wide margin in 2024, and volume shouldn't be an issue this weekend against the Pittsburgh Steelers, especially with rookie Devaughn Vele (ribs), who had eight targets in the season opener, ruled out. However, Sutton is going to need to be more efficient with Nix to be a worthwhile WR4/flex play on a weekly basis for fantasy managers. The Steelers held Falcons WR1 Drake London to only two catches for 15 yards last week and present another difficult matchup for Nix and this new-look Broncos offense. Don't be surprised if Sutton struggles with efficiency again in the team's home opener.

The good news for Denver Broncos wide receiver Courtland Sutton in the team's 26-20 Week 1 loss to the Seattle Seahawks at Lumen Field on Sunday was that he led the team with 12 targets. However, Sutton could only connect with rookie first-round quarterback Bo Nix four times for just 38 receiving yards in a day in which Nix looked a bit overmatched in his NFL debut against a fired-up defense in a hostile environment. The 28-year-old Sutton is certainly going to have ups and downs in 2024 while working with a rookie signal-caller. It's clear that Nix is going to target Sutton plenty as the WR1 in Denver, but Sutton's fantasy managers couldn't have been thrilled with rookie Devaughn Vele drawing eight targets of his own in his NFL debut. The Pittsburgh Steelers won't pose a much easier matchup in Week 2, where Sutton will set up as a touchdown-dependent WR4/flex.