Mahomes (knee) doesn't have an injury designation for Monday's game against the Broncos.

Mahomes was a full participant in all three practices during Week 1 prep, and the 30-year-old quarterback is officially good to go for Monday's season opener. His mobility could still be limited, as he'll be wearing a protective brace on the left knee in which he tore both his ACL and LCL in Week 15 of last season. The brace could restrict his ability to move around the pocket and scramble out of trouble, which could loom large with undrafted rookie Khalil Benson expected to start at left tackle while Josh Simmons (back) sits out.

Mahomes (knee) opened Week 1 prep as a full practice participant Thursday.

Per Charles Goldman of AtoZSports.com, head coach Andy Reid relayed prior to the Chiefs' first official practice of Week 1 that Mahomes was "geared up and ready to go" for the season opener Monday versus the Broncos. The quarterback backed up his coach's optimism by taking every rep with the first-team offense Thursday, setting the stage for him to play in his first game since his 2025 season came to an end Dec. 14, when he sustained a torn ACL and LCL in his left knee. Mahomes made tremendous strides in his rehab from surgery and was cleared for full practices prior to training camp, and though he didn't play in any preseason games, he steered clear of any setbacks with his knee. According to Matt Derrick of ChiefsDigest.com, Mahomes said that he'll continue to wear a protective brace on his knee, and while the Chiefs aren't expected to alter their game plans as a result, the 30-year-old could naturally scale back his involvement as a runner coming off major surgery.

Kansas City head coach Andy Reid said Tuesday that Mahomes (knee) has a "pretty good chance" to start next Monday's season opener versus the Broncos, Sam McDowell of The Kansas City Star reports.

Mahomes didn't play in any preseason games, but he was cleared for 11-on-11 work early in camp and steered clear of any setbacks in his recovery from Dec. 15 surgery to repair a torn ACL and LCL in his left knee. Kansas City will release its first injury report Thursday, and assuming the star QB is listed as a full participant, it would confirm that he's on track to start against Denver. Mahomes will likely be playing without one of his top protectors, however, as Reid said that starting left tackle Josh Simmons (back) has a "good chance" of sitting out Week 1, per Matt McMullen of the team's official site.

Gainwell rushed five times for 15 yards and brought in his lone target for three yards in the Buccaneers' 33-27 loss to the Bengals on Sunday. He also returned one kickoff for 22 yards.

Gainwell worked in the No. 2 role as expected, and with Sean Tucker (hamstring) unavailable Sunday, the former saw a sizable share of the Buccaneers' 13 running back touches. The ground attack took a back seat overall due to game script, but next Sunday's Week 2 home matchup against the Browns could certainly see pretty drastic change for the better in that regard, a development that would particularly benefit Gainwell if Tucker remains sidelined.

Gainwell is one of three running backs on Tampa Bay's 53-man roster, along with Bucky Irving and Sean Tucker (undisclosed), the latter of whom didn't practice Wednesday, per Greg Auman of Fox Sports.

Gainwell signed a two-year, $14 million contract with the Buccaneers in March after leading the Steelers with 73 catches in the 2025 regular season. He's likely to fill a change-of-pace role while playing primarily in passing situations, much like Rachaad White did for the past couple seasons in a Buccaneers backfield that's expected to be led by Irving as long as the latter stays healthy. Tucker could be a thorn in the side of both Gainwell and Irving from a fantasy perspective if Tucker reprises his red-zone role from 2025, which helped him punch in a team-high seven rushing touchdowns.

Downs caught two of four targets for 37 yards in Sunday's 41-23 loss to the Ravens.

Downs' four targets tied Jonathan Taylor for fourth on the team behind Alec Pierce (six), Keenan Allen (six) and Tyler Warren (five), but it was notable that Downs led the team with 32 routes on Daniel Jones' 34 dropbacks. He was in the slot 78.8 percent of the time, and his 93.8 percent route participation suggests Downs is an every-down wideout this season after playing behind both Michael Pittman and Pierce in previous seasons. Downs should have better days moving forward and gets a Week 2 date with the Chiefs next Sunday.

Downs (calf) is not on the Colts' injury report Wednesday.

The fourth-year receiver downplayed the calf injury that slowed him towards the end of summer. Downs evaded the injury report entirely Wednesday, signaling that he should be ready to go for the opener against the Ravens. Indianapolis may be at full strength at receiver with Alec Pierce trending in the right direction as well.

Downs (calf) was spotted on the field participating in Tuesday's practice, Jake Arthur of Roundtable.io reports.

Downs missed some practice time last week with what he termed as a "very minor" calf injury. The Colts will release their first Week 1 injury report Sept. 9, and if his activity Tuesday is any indication, Downs could be off the report entirely as the team prepares for its season opener against the Ravens.

Little went 2-for-2 on field-goal attempts and made all four of his PATs in Sunday's 34-10 win over the Browns.

After finishing as fantasy's K5 overall last regular season, Little picked up right where he left off in Week 1 against Cleveland. His field-goal makes came from 47 and 40 yards Sunday, and he's now 31-for-37 on field goals from 40-plus yards out across 35 career regular-season contests. The big-legged Little is an every-week K1 in this Jacksonville offense.

Stroud completed 26 of 38 passes for 274 yards and two touchdowns in Sunday's 36-31 loss to the Bills. He also rushed twice for 15 yards and fumbled twice, losing both fumbles.

Stroud and the Texans will wait until after the 2026 season to work out a long-term contract extension, Adam Schefter of ESPN reports.

Stroud heads into the regular season with Nico Collins, Xavier Hutchinson, Jaylin Noel (hamstring) and Kayshon Boutte as his top wide receivers, while Jonathan M. Alexander of the Houston Chronicle reports that Tank Dell (knee) will begin the season on IR with a designation to return.

Robinson rushed nine times for 31 yards in the Falcons' 20-13 loss to the Steelers on Sunday.

The Athletic's Josh Kendall expects Robinson to have a goal-line role for the Falcons this season.

Boutte caught one of two targets for 21 yards in the Texans' 36-31 loss to the Bills on Sunday.

Boutte said Wednesday that he's been developing chemistry with QB C.J. Stroud since his trade from the Patriots to the Texans on Aug. 24, Cole Thompson of USA Today reports.