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San Francisco 49ers wide receiver Jauan Jennings will try to continue his unlikely run as a fantasy difference-maker when the team squares off against the Arizona Cardinals at home on Sunday. Against New England last week, Jennings paced all 49ers receivers with three receptions on six targets for 88 yards. It was one thing for Jennings to have a career day in Week 3 with Deebo Samuel Sr. and George Kittle absent, but it was quite the surprise to follow it up with a fantasy-useful performance with everyone healthy. Arizona's pass defense is tied for 14th in half-PPR points allowed to opposing wide receivers, which makes for a decent opportunity for San Francisco's receivers. However, Jennings is still a dubious bet to continue producing like he has, given the talent of Samuel Sr., Kittle, and Brandon Aiyuk demanding targets. Jennings is a consensus WR4 and a risky FLEX play in Week 5.

San Francisco 49ers wide receiver Deebo Samuel Sr. will line up against the Arizona Cardinals at home on Sunday. Last week versus New England, Samuel Sr. caught three of five targets for 58 yards plus two carries for 14 yards rushing after spending some time on the injury report. His day, disappointing as it was, was somewhat saved by a single 53-yard reception. Arizona, coming into the game tied for 14th in half-PPR fantasy points allowed to wide receivers, represents a decent opportunity for Samuel Sr. Also worth noting is that the Cardinals' defense has been sixth-worst against the run and Samuel Sr. usually gets at least a couple of carries. He's averaging 13 half-PPR points in fantasy so far. Start a healthy Samuel Sr. as a back-end WR1 in Week 5.

Chicago Bears kicker Cairo Santos is a solid fantasy option for Week 5 against the Carolina Panthers. Although he has struggled in the past two weeks, managing only one field goal in each game, he did convert all three of his extra point attempts and his lone field goal in the Bears' 24-18 victory over the Los Angeles Rams in Week 4, totaling six points. As one of the top streaming kickers and a viable bye-week replacement, Santos has a favorable matchup this week. The Panthers allow a league-high 32.3 points per game and an average of 2.3 field goals per contest. With this in mind, the veteran kicker presents an appealing lineup option for fantasy managers in Week 5.

Chicago Bears tight end Cole Kmet is a borderline starter this week, thanks to a favorable matchup against the struggling Carolina Panthers secondary. In Week 5, Kmet will face the 19th-ranked pass defense in the NFL, which allows an average of 209.3 yards per game, presenting a solid opportunity for him. However, with all three starting wide receivers now healthy, Kmet's usage has reverted to more typical levels following his breakout in Week 3. He has been held to under 35 receiving yards in three of his four games this season. Kmet appeared on the Bears' first practice report for Week 5 as limited due to a knee injury. Still, he participated fully in practice the following day, likely clearing him for Sunday's matchup against the Panthers. He has a chance to score this week, as the Panthers have allowed multiple touchdown passes in every game this season.

Chicago Bears rookie wide receiver Rome Odunze is set for a bounce back this Sunday against a vulnerable Carolina Panthers secondary. In Week 5, Odunze will go up against the 19th-ranked pass defense in the league, allowing an average of 209.3 yards per gamean encouraging matchup for him. He has a chance to score this week, as the Panthers have surrendered multiple touchdown passes in every game this season. Last week, Caleb Williams missed Odunze on a potential deep touchdown against the Los Angeles Rams, but both players are improving with each game. While Odunze's long-term potential is clear, his current 14.9% target rateranking 78th among wide receiversmakes him less appealing as a fantasy starter. He won't be a reliable option until the Bears' offense finds its rhythm or Odunze surpasses Allen in targets. However, with a favorable matchup against the Panthers, he could see the end zone, positioning him as a WR4 with significant risks and potential rewards.

Chicago Bears wide receiver Keenan Allen (heel) aims to bounce back this Sunday in Chicago against a notably weak Carolina Panthers secondary. After missing some time due to a heel injury, Allen returned last week but saw limited action, with just three targets and seven air yards. The Bears' offense has struggled to succeed in the passing game, making target competition a mess. In Week 5, however, Allen will go up against the 19th-ranked pass defense in the NFL, allowing an average of 209.3 yards per gamean advantageous matchup. He has a solid opportunity to find the end zone, as the Panthers have given up multiple touchdown passes in every game this season. Although the Bears' overall lack of passing volume has hindered Allen's production, a healthier status combined with a favorable matchup could lead to a more productive fantasy outing. He's currently a WR3, but if the Bears are forced to throw, he can exceed that expectation.

Chicago Bears wide receiver DJ Moore is a strong WR2 option this week against the struggling Carolina Panthers secondary. Moore is tied for seventh in the NFL for red zone targets, helping to maintain his fantasy value. Although he had a modest performance last week, he salvaged it with a touchdown. In last year's matchup against the Panthers, Moore led the Bears with five receptions for 58 yards, playing alongside Tyson Bagent in place of the injured Justin Fields. With Moore and Caleb Williams developing chemistry, the veteran wideout could have a standout game against Carolina on Sunday. He aims to exploit a shaky Panthers defense in Week 5 and would love to prove them wrong for trading him, especially in what is expected to be a high-scoring affair.

Chicago Bears running back Roschon Johnson is set to build on his increased usage in Week 5 against the Carolina Panthers. He aims to capitalize on a favorable matchup against a Panthers defense ranked 29th in the league, allowing an average of 148.8 rushing yards per game. While Johnson maintained a consistent snap rate of 37% in Week 4 and he only had seven touches for 26 rushing yards, he didn't see a significant uptick in his offensive role. Meanwhile, D'Andre Swift regained the lead in red zone snaps, which bodes well for his fantasy prospects. However, Johnson has shown himself to be an effective runner between the tackles, particularly in short-yardage situations. Given the Panthers' struggles against the run, Johnson could be a worthwhile option as a high-end RB4 for those hoping for a touchdown opportunity.

Chicago Bears running back D'Andre Swift is a solid RB3 for Sunday's game against the Carolina Panthers, presenting a promising opportunity. Last week, he had his best performance of the season against the Rams, totaling 16 carries for 93 yards, one touchdown, and seven receptions for 72 yards. Before Week 4, Swift had struggled, not exceeding 30 rushing yards or 24 receiving yards in any game. He led all Bears players in carries, rushing yards, targets, receptions, and receiving yards while scoring a touchdown. Although it's concerning that Roschon Johnson handled the goal-line work, Swift's overall snap distribution keeps him relevant. He demonstrated his potential in a favorable matchup, and the Panthers have allowed the second-most rushing yards and touchdowns to running backs. In Week 5, Swift will look to capitalize on this advantageous matchup against Carolina's 29th-ranked run defense, which concedes an average of 148.8 yards per game.

This Sunday, Chicago Bears rookie quarterback Caleb Williams offers a high-risk, high-reward choice as he faces the struggling Carolina Panthers. In Week 5, Williams will encounter the NFL's 19th-ranked pass defense, which allows an average of 209.3 yards per gamean advantageous matchup for him. He's poised to find the end zone against the Panthers, who have given up multiple touchdown passes in every game this season. After throwing for 363 yards and two touchdowns in Week 3, Williams had a quieter performance with just 157 yards in Week 4. It's reasonable to anticipate his production will land between those outings, aiming for at least 225 passing yards and a couple of scores this Sunday in Chicago. Williams emerges as a solid QB2 with significant upside in this favorable matchup as he seeks to impress fantasy managers.